RRC ID 6224
著者 Wada H, Okamoto H.
タイトル Roles of planar cell polarity pathway genes for neural migration and differentiation.
ジャーナル Dev Growth Differ
Abstract Planar cell polarity (PCP) in epithelial cells is essential for the organization of tissues and their functions. The conserved non-canonical Wnt/PCP pathway regulates this process in both Drosophila and vertebrates. However, recent studies have revealed that a similar set of genes, which may not be related to PCP, regulates oriented cell movement during development. In the present review, recent findings on neural migration in zebrafish hindbrain and axonal guidance in mouse forebrain and spinal cord are discussed. Future analyses on defects in vertebrate PCP mutants will provide novel insights into the conserved and diverse roles of non-canonical Wnt/PCP pathway genes in vertebrate brain development.
巻・号 51(3)
ページ 233-40
公開日 2009-4-1
DOI 10.1111/j.1440-169X.2009.01092.x
PII DGD1092
PMID 19298553
MeSH Animals Cell Differentiation / genetics Cell Differentiation / physiology* Cell Movement / genetics Cell Movement / physiology* Cell Polarity / genetics Cell Polarity / physiology* Drosophila Mice Neurons / cytology* Neurons / metabolism* Prosencephalon / anatomy & histology Prosencephalon / cytology Prosencephalon / metabolism Signal Transduction Spinal Cord / anatomy & histology Spinal Cord / cytology Spinal Cord / metabolism Zebrafish
IF 1.723
引用数 22
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ゼブラフィッシュ Review