論文 - 詳細
| RRC ID | 62840 |
|---|---|
| 著者 | Koshizuka T, Inoue N. |
| タイトル | Activation of c-Jun by human cytomegalovirus UL42 through JNK activation. |
| ジャーナル | PLoS One |
| Abstract |
c-Jun is a major component of the AP-1 transactivator complex. In this report, we demonstrated that AP-1 was activated by the expression of UL42, a human cytomegalovirus-encoded membrane protein that has two PPXY (PY) motifs and a C-terminal transmembrane domain (TMD). Although UL42 interacts with Itch, an ubiquitin E3 ligase, through the PY motifs, UL42 phosphorylated c-Jun and c-Jun N-terminal kinase (JNK) in the absence of any interaction with Itch. Experiments using mutated versions of UL42 suggest the importance of the carboxyl half (a.a. 52-124) of UL42 for the activation of the JNK signaling, while C-terminal TMD alone is not sufficient. Thus, we hypothesize that UL42 plays a role in the activation of JNK signaling in HCMV-infected cells. (118 words). |
| 巻・号 | 15(5) |
| ページ | e0232635 |
| 公開日 | 2020-1-1 |
| DOI | 10.1371/journal.pone.0232635 |
| PII | PONE-D-20-02197 |
| PMID | 32369499 |
| PMC | PMC7199950 |
| MeSH | Cytomegalovirus / metabolism* Enzyme Activation HEK293 Cells Humans JNK Mitogen-Activated Protein Kinases / metabolism* Phosphorylation Proto-Oncogene Proteins c-jun / biosynthesis* Repressor Proteins / metabolism Ubiquitin-Protein Ligases / metabolism Viral Proteins / metabolism* |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |