Reference - Detail
| RRC ID | 6312 |
|---|---|
| Author | Amin NM, Lim SE, Shi H, Chan TL, Liu J. |
| Title | A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. |
| Journal | Dev Biol |
| Abstract |
The subdivision of mesodermal cells into muscle and non-muscle cells is crucial to animal development. In the C. elegans postembryonic mesoderm, this subdivision is a result of an asymmetric cell division that leads to the formation of striated body wall muscles and non-muscle coelomocytes. Here we report that the Six homeodomain protein CEH-34 and its cofactor Eyes Absent, EYA-1, function synergistically to promote the non-muscle fate in cells also competent to form muscles. We further show that the asymmetric expression of ceh-34 and eya-1 is regulated by a combination of 1) mesodermal intrinsic factors MAB-5, HLH-1 and FOZI-1, 2) differential POP-1 (TCF/LEF) transcriptional activity along the anterior-posterior axis, and 3) coelomocyte competence factor(s). These factors are conserved in both vertebrates and invertebrates, suggesting a conserved paradigm for mesoderm development in metazoans. |
| Volume | 331(2) |
| Pages | 350-60 |
| Published | 2009-7-15 |
| DOI | 10.1016/j.ydbio.2009.05.538 |
| PII | S0012-1606(09)00303-0 |
| PMID | 19427847 |
| PMC | PMC2703692 |
| MeSH | Animals Animals, Genetically Modified Antigens, Differentiation / metabolism Caenorhabditis elegans / embryology Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation, Developmental Homeodomain Proteins / metabolism* Intracellular Signaling Peptides and Proteins / metabolism* Mesoderm / growth & development Mesoderm / physiology* Muscle Development Muscles / cytology Muscles / embryology Nuclear Proteins / metabolism* Protein Tyrosine Phosphatases / metabolism* Signal Transduction / physiology Transcription Factors / metabolism* Wnt Proteins / metabolism* |
| IF | 2.896 |
| Times Cited | 19 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| C.elegans | tm3330 tm3733 |