RRC ID 6396
Author Pirri JK, McPherson AD, Donnelly JL, Francis MM, Alkema MJ.
Title A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.
Journal Neuron
Abstract A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.
Volume 62(4)
Pages 526-38
Published 2009-5-28
DOI 10.1016/j.neuron.2009.04.013
PII S0896-6273(09)00294-3
PMID 19477154
PMC PMC2804440
MeSH Adrenergic Uptake Inhibitors / pharmacology* Analysis of Variance Animals Animals, Genetically Modified Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins Chloride Channels / genetics Chloride Channels / physiology* Dose-Response Relationship, Drug Electric Stimulation / methods Escape Reaction / physiology* Gene Expression / drug effects Green Fluorescent Proteins / genetics Head Movements / drug effects Ion Channel Gating / drug effects* Locomotion / drug effects Locomotion / genetics Membrane Potentials / drug effects Membrane Potentials / genetics Mutation / genetics Neck Muscles / metabolism Oocytes / drug effects Oocytes / physiology Patch-Clamp Techniques Physical Stimulation / methods Sequence Analysis, Protein Tyramine / pharmacology* Xenopus laevis
IF 14.403
Times Cited 61
C.elegans tm2913