論文 - 詳細
| RRC ID | 6396 |
|---|---|
| 著者 | Pirri JK, McPherson AD, Donnelly JL, Francis MM, Alkema MJ. |
| タイトル | A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response. |
| ジャーナル | Neuron |
| Abstract |
A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response. |
| 巻・号 | 62(4) |
| ページ | 526-38 |
| 公開日 | 2009-5-28 |
| DOI | 10.1016/j.neuron.2009.04.013 |
| PII | S0896-6273(09)00294-3 |
| PMID | 19477154 |
| PMC | PMC2804440 |
| MeSH | Adrenergic Uptake Inhibitors / pharmacology* Analysis of Variance Animals Animals, Genetically Modified Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins Chloride Channels / genetics Chloride Channels / physiology* Dose-Response Relationship, Drug Electric Stimulation / methods Escape Reaction / physiology* Gene Expression / drug effects Green Fluorescent Proteins / genetics Head Movements / drug effects Ion Channel Gating / drug effects* Locomotion / drug effects Locomotion / genetics Membrane Potentials / drug effects Membrane Potentials / genetics Mutation / genetics Neck Muscles / metabolism Oocytes / drug effects Oocytes / physiology Patch-Clamp Techniques Physical Stimulation / methods Sequence Analysis, Protein Tyramine / pharmacology* Xenopus laevis |
| IF | 14.415 |
| 引用数 | 86 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm2913 |