論文 - 詳細
| RRC ID | 6408 |
|---|---|
| 著者 | Mets DG, Meyer BJ. |
| タイトル | Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure. |
| ジャーナル | Cell |
| Abstract |
Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation. CO distribution is tightly regulated: homolog pairs receive at least one CO, CO spacing is nonrandom, and COs occur preferentially in short genomic intervals called hotspots. We show that CO number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand break (DSB) formation by a condensin complex composed of subunits from two known condensins: the C. elegans dosage compensation complex and mitotic condensin II. Disruption of any subunit of the CO-controlling condensin dominantly changes DSB distribution, and thereby COs, and extends meiotic chromosome axes. These phenotypes are cosuppressed by disruption of a chromosome axis element. Our data implicate higher-order chromosome structure in the regulation of CO recombination, provide a model for the rapid evolution of CO hotspots, and show that reshuffling of interchangeable molecular parts can create independent machines with similar architectures but distinct biological functions. |
| 巻・号 | 139(1) |
| ページ | 73-86 |
| 公開日 | 2009-10-2 |
| DOI | 10.1016/j.cell.2009.07.035 |
| PII | S0092-8674(09)00915-5 |
| PMID | 19781752 |
| PMC | PMC2785808 |
| MeSH | Adenosine Triphosphatases / genetics Adenosine Triphosphatases / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Chromosomal Proteins, Non-Histone Crossing Over, Genetic* DNA Breaks, Double-Stranded DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Humans Meiosis* Multiprotein Complexes / genetics Multiprotein Complexes / metabolism* Mutation Rad51 Recombinase / metabolism |
| IF | 38.637 |
| 引用数 | 142 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1514 tm1860 |