論文 - 詳細
| RRC ID | 64554 |
|---|---|
| 著者 | Izumi Y, Fujii K, Wien F, Houée-Lévin C, Lacombe S, Salado-Leza D, Porcel E, Masoud R, Yamamoto S, Réfrégiers M, Hervé du Penhoat MA, Yokoya A. |
| タイトル | Structure Change from β-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response. |
| ジャーナル | Biophys J |
| Abstract |
Using synchrotron radiation-based circular dichroism spectroscopy, we found that the DNA damage response induces an increase of α-helix structure and a decrease of β-strand and turn structures in histone H2A-H2B extracted from x-irradiated human HeLa cells. The structural alterations correspond to the assumption that an average of eight amino acid residues form new α-helix structures at 310 K. We propose the structural transition from β-strand and turn structures to an α-helix structure in H2A-H2B as a novel, to our knowledge, process involved in the DNA damage response. |
| 巻・号 | 111(1) |
| ページ | 69-78 |
| 公開日 | 2016-7-12 |
| DOI | 10.1016/j.bpj.2016.06.002 |
| PII | S0006-3495(16)30399-X |
| PMID | 27410735 |
| PMC | PMC4945303 |
| MeSH | DNA Damage* HeLa Cells Histones / chemistry* Histones / metabolism Humans Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Temperature Ubiquitination |
| IF | 3.854 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa/Fucci(RCB2812) |