| RRC ID |
64807
|
| 著者 |
Chang W, Pedroni A, Hohendorf V, Giacomello S, Hibi M, Köster RW, Ampatzis K.
|
| タイトル |
Functionally distinct Purkinje cell types show temporal precision in encoding locomotion.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. Dual patch-clamp recordings showed that the cerebellar circuit contains all Purkinje cell types that cross-communicate extensively using chemical and electrical synapses. Further activation of spinal central pattern generators (CPGs) revealed unique phase-locked activity from each Purkinje cell type during the locomotor cycle. Thus, we show intricately organized Purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions.
|
| 巻・号 |
117(29)
|
| ページ |
17330-17337
|
| 公開日 |
2020-7-21
|
| DOI |
10.1073/pnas.2005633117
|
| PII |
2005633117
|
| PMID |
32632015
|
| PMC |
PMC7382291
|
| MeSH |
Action Potentials
Animals
Behavior, Animal
Brain
Central Pattern Generators / physiology
Cerebellum / physiology
Cluster Analysis
Electrophysiological Phenomena
Female
Locomotion / physiology*
Male
Models, Animal
Purkinje Cells / physiology*
Spinal Cord
Zebrafish / physiology*
|
| IF |
9.412
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(aldoca:BoTx-GFP) |
