論文 - 詳細
| RRC ID | 64813 |
|---|---|
| 著者 | Saito Y, Nakamura S, Chinen N, Shimazawa M, Hara H. |
| タイトル | Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model. |
| ジャーナル | J Pharmacol Sci |
| Abstract |
There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days following the removal of scales. Hence, the dexamethasone-induced regenerating scale malformation model may be a useful animal model for discovering drugs to treat GIOP. |
| 巻・号 | 143(2) |
| ページ | 117-121 |
| 公開日 | 2020-6-1 |
| DOI | 10.1016/j.jphs.2020.02.011 |
| PII | S1347-8613(20)30027-X |
| PMID | 32220570 |
| MeSH | Animal Scales / pathology* Animal Scales / physiology* Animals Bone Density Conservation Agents / pharmacology Bone Density Conservation Agents / therapeutic use* Dexamethasone / adverse effects* Disease Models, Animal* Osteoporosis / chemically induced* Osteoporosis / drug therapy* Phenotype Regeneration* / drug effects Zebrafish |
| IF | 2.835 |
| リソース情報 | |
| ゼブラフィッシュ | RIKEN WT |