論文 - 詳細
| RRC ID | 64818 |
|---|---|
| 著者 | Ma W, Zhou J, Chen J, Carr AM, Watanabe Y. |
| タイトル | Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I. |
| ジャーナル | Genes Dev |
| Abstract |
The conserved meiosis-specific kinetochore regulator, meikin (Moa1 in fission yeast) plays a central role in establishing meiosis-specific kinetochore function. However, the underlying molecular mechanisms remain elusive. Here, we show how Moa1 regulates centromeric cohesion protection, a function that has been previously attributed to shugoshin (Sgo1). Moa1 is known to associate with Plo1 kinase. We explore Plo1-dependent Rec8 phosphorylation and identify a key phosphorylation site required for cohesion protection. The phosphorylation of Rec8 by Moa1-Plo1 potentiates the activity of PP2A associated with Sgo1. This leads to dephosphorylation of Rec8 at another site, which thereby prevents cleavage of Rec8 by separase. |
| 巻・号 | 35(9-10) |
| ページ | 692-697 |
| 公開日 | 2021-5-1 |
| DOI | 10.1101/gad.348052.120 |
| PII | gad.348052.120 |
| PMID | 33888556 |
| PMC | PMC8091969 |
| MeSH | Cell Cycle Proteins / metabolism* Chromosomal Proteins, Non-Histone / metabolism* Meiosis / genetics* Phosphoproteins / metabolism Phosphorylation / genetics Protein Serine-Threonine Kinases / metabolism Schizosaccharomyces / enzymology Schizosaccharomyces / genetics* Schizosaccharomyces / metabolism* Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Separase / metabolism |
| IF | 9.527 |
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