論文 - 詳細
| RRC ID | 65155 |
|---|---|
| 著者 | Falchook GS, Kurzrock R, Amin HM, Xiong W, Fu S, Piha-Paul SA, Janku F, Eskandari G, Catenacci DV, Klevesath M, Bruns R, Stammberger U, Johne A, Bladt F, Friese-Hamim M, Girard P, El Bawab S, Hong DS. |
| タイトル | First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors. |
| ジャーナル | Clin Cancer Res |
| Abstract |
PURPOSE:Tepotinib is an oral, potent, highly selective MET inhibitor. This first-in-man phase I trial investigated the MTD of tepotinib to determine the recommended phase II dose (RP2D). PATIENTS AND METHODS:Patients received tepotinib orally according to one of three dose escalation regimens (R) on a 21-day cycle: R1, 30-400 mg once daily for 14 days; R2, 30-315 mg once daily 3 times/week; or R3, 300-1,400 mg once daily. After two cycles, treatment could continue in patients with stable disease until disease progression or unacceptable toxicity. The primary endpoint was incidence of dose-limiting toxicity (DLT) and treatment-emergent adverse events (TEAE). Secondary endpoints included safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor effects. RESULTS:One hundred and forty-nine patients received tepotinib (R1: n = 42; R2: n = 45; R3: n = 62). Although six patients reported DLTs [one patient in R1 (115 mg), three patients in R2 (60, 100, 130 mg), two patients in R3 (1,000, 1,400 mg)], the MTD was not reached at the highest tested dose of 1,400 mg daily. The RP2D of tepotinib was established as 500 mg once daily, supported by translational modeling data as sufficient to achieve ≥95% MET inhibition in ≥90% of patients. Treatment-related TEAEs were mostly grade 1 or 2 fatigue, peripheral edema, decreased appetite, nausea, vomiting, and lipase increase. The best overall response in R3 was partial response in two patients, both with MET overexpression. CONCLUSIONS:Tepotinib was well tolerated with clinical activity in MET-dysregulated tumors. The RP2D of tepotinib was established as 500 mg once daily. MET abnormalities can drive tumorigenesis. This first-in-man trial demonstrated that the potent, highly selective MET inhibitor tepotinib can reduce or stabilize tumor burden and is well tolerated at doses up to 1,400 mg once daily. An RP2D of 500 mg once daily, as determined from translational modeling and simulation integrating human population pharmacokinetic and pharmacodynamic data in tumor biopsies, is being used in ongoing clinical trials. |
| 巻・号 | 26(6) |
| ページ | 1237-1246 |
| 公開日 | 2020-3-15 |
| DOI | 10.1158/1078-0432.CCR-19-2860 |
| PII | 1078-0432.CCR-19-2860 |
| PMID | 31822497 |
| MeSH | Adult Aged Aged, 80 and over Dose-Response Relationship, Drug Female Humans Male Maximum Tolerated Dose Middle Aged Nausea / chemically induced Neoplasms / drug therapy* Neoplasms / pathology Patient Safety Piperidines / pharmacokinetics* Piperidines / therapeutic use* Protein Kinase Inhibitors / pharmacokinetics Protein Kinase Inhibitors / therapeutic use Proto-Oncogene Proteins c-met / antagonists & inhibitors* Pyridazines / pharmacokinetics* Pyridazines / therapeutic use* Pyrimidines / pharmacokinetics* Pyrimidines / therapeutic use* Tissue Distribution Treatment Outcome Vomiting / chemically induced Young Adult |
| IF | 10.107 |
| リソース情報 | |
| ヒト・動物細胞 | KP4(RCB1005) |