論文 - 詳細
| RRC ID | 65296 |
|---|---|
| 著者 | Heimbucher T, Hog J, Gupta P, Murphy CT. |
| タイトル | PQM-1 controls hypoxic survival via regulation of lipid metabolism. |
| ジャーナル | Nat Commun |
| Abstract |
Animals have evolved responses to low oxygen conditions to ensure their survival. Here, we have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of the hypoxic stress response. PQM-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic conditions. PQM-1 functions as a metabolic regulator by controlling oxygen consumption rates, suppressing hypoxic glycogen levels, and inhibiting the expression of the sorbitol dehydrogenase-1 SODH-1, a crucial sugar metabolism enzyme. PQM-1 promotes hypoxic fat metabolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis. PQM-1 activity positively regulates fat transport to developing oocytes through vitellogenins under hypoxic conditions, thereby increasing survival rates of arrested progeny during hypoxia. Thus, while pqm-1 mutants increase survival of mothers, ultimately this loss is detrimental to progeny survival. Our data support a model in which PQM-1 controls a trade-off between lipid metabolic activity in the mother and her progeny to promote the survival of the species under hypoxic conditions. |
| 巻・号 | 11(1) |
| ページ | 4627 |
| 公開日 | 2020-10-2 |
| DOI | 10.1038/s41467-020-18369-w |
| PII | 10.1038/s41467-020-18369-w |
| PMID | 33009389 |
| PMC | PMC7532158 |
| MeSH | Animals Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Embryo, Mammalian / metabolism Gene Expression Regulation Glycogen / metabolism Hypoxia / metabolism* Insulin / metabolism Larva / metabolism Lipid Metabolism* Mutation / genetics Oxygen Consumption Signal Transduction Stress, Physiological Survival Analysis Trans-Activators / genetics Trans-Activators / metabolism* Transcription, Genetic Vitellogenins / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |