論文 - 詳細
| RRC ID | 65314 |
|---|---|
| 著者 | Guan L, Zhan Z, Yang Y, Miao Y, Huang X, Ding M. |
| タイトル | Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. |
| ジャーナル | PLoS Genet |
| Abstract |
ER stress occurs in many physiological and pathological conditions. However, how chronic ER stress is alleviated in specific cells in an intact organism is an outstanding question. Here, overexpressing the gap junction protein UNC-9 (Uncoordinated) in C. elegans neurons triggers the Ire1-Xbp1-mediated stress response in an age-dependent and cell-autonomous manner. The p38 MAPK PMK-3 regulates the chronic stress through IRE-1 phosphorylation. Overexpressing gap junction protein also activates autophagy. The insulin pathway functions through autophagy, but not the transcription of genes encoding ER chaperones, to counteract the p38-Ire1-Xbp1-mediated stress response. Together, these results reveal an intricate cellular regulatory network in response to chronic stress in a subset of cells in multicellular organism. |
| 巻・号 | 16(9) |
| ページ | e1008704 |
| 公開日 | 2020-9-1 |
| DOI | 10.1371/journal.pgen.1008704 |
| PII | PGENETICS-D-20-00285 |
| PMID | 32986702 |
| PMC | PMC7544145 |
| MeSH | Animals Animals, Genetically Modified Autophagy / physiology* Caenorhabditis elegans / cytology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism Endoplasmic Reticulum Stress / physiology* Green Fluorescent Proteins / genetics Heat-Shock Proteins / genetics Heat-Shock Proteins / metabolism Insulin / metabolism* Membrane Proteins / genetics Membrane Proteins / metabolism Mitogen-Activated Protein Kinases / genetics Mitogen-Activated Protein Kinases / metabolism Mutation Neurons / metabolism* Phosphorylation Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism Stress, Physiological Unfolded Protein Response / physiology |
| リソース情報 | |
| 線虫 | tm745 tm4024 tm2457 tm2482 tm2927 tm1153 tm1344 tm4305 tm4136 tm629 |