Reference - Detail
| RRC ID | 6596 |
|---|---|
| Author | Uddin MH, Otsuka M, Muroi T, Ono A, Hanif N, Matsuda S, Higa T, Tanaka J. |
| Title | Deoxymanoalides from the nudibranch Chromodoris willani. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
Two sesterterpenes, deoxymanoalide (1) and deoxysecomanoalide (2), were isolated from the nudibranch Chromodoris willani collected in Okinawa and their structures determined on the basis of spectroscopic data and chemical conversions. The mollusk feeds on a sponge containing manoalide (3) and secomanoalide (4) and is likely to biotransform them into 1 and 2. Both 1 and 2 showed moderate antimicrobial activity against Escherichia coli and Bacillus subtilis and inhibited snake venom phospholipase A2 at 0.2 to 0.5 microM. |
| Volume | 57(8) |
| Pages | 885-7 |
| Published | 2009-8-1 |
| DOI | 10.1248/cpb.57.885 |
| PII | JST.JSTAGE/cpb/57.885 |
| PMID | 19652420 |
| MeSH | Animals Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Bacillus subtilis / drug effects* Cell Line Cell Survival / drug effects Dose-Response Relationship, Drug Drug Evaluation, Preclinical Enzyme Inhibitors / chemistry Enzyme Inhibitors / isolation & purification Enzyme Inhibitors / pharmacology* Escherichia coli / drug effects* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy / standards Microbial Sensitivity Tests Molecular Conformation Mollusca / chemistry* Phospholipase A2 Inhibitors* Rats Reference Standards Sesterterpenes / chemistry Sesterterpenes / isolation & purification Sesterterpenes / pharmacology* Snake Venoms / enzymology Stereoisomerism |
| IF | 1.416 |
| Times Cited | 13 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Resource | |
| Human and Animal Cells | |