論文 - 詳細
| RRC ID | 6698 |
|---|---|
| 著者 | Benghezal M, Cornillon S, Gebbie L, Alibaud L, Brückert F, Letourneur F, Cosson P. |
| タイトル | Synergistic control of cellular adhesion by transmembrane 9 proteins. |
| ジャーナル | Mol Biol Cell |
| Abstract |
The transmembrane 9 (TM9) family of proteins contains numerous members in eukaryotes. Although their function remains essentially unknown in higher eukaryotes, the Dictyostelium discoideum Phg1a TM9 protein was recently reported to be essential for cellular adhesion and phagocytosis. Herein, the function of Phg1a and of a new divergent member of the TM9 family called Phg1b was further investigated in D. discoideum. The phenotypes of PHG1a, PHG1b, and PHG1a/PHG1b double knockout cells revealed that Phg1a and Phg1b proteins play a synergistic but not redundant role in cellular adhesion, phagocytosis, growth, and development. Complementation analysis supports a synergistic regulatory function rather than a receptor role for Phg1a and Phg1b proteins. Together, these results suggest that Phg1 proteins act as regulators of cellular adhesion, possibly by controlling the intracellular transport in the endocytic pathway and the composition of the cell surface. |
| 巻・号 | 14(7) |
| ページ | 2890-9 |
| 公開日 | 2003-7-1 |
| DOI | 10.1091/mbc.e02-11-0724 |
| PII | E02-11-0724 |
| PMID | 12857872 |
| PMC | PMC165684 |
| MeSH | Amino Acid Sequence Animals Cell Adhesion / physiology Cell Membrane / metabolism Cell Membrane / physiology Dictyostelium / growth & development Dictyostelium / metabolism* Membrane Proteins / metabolism* Membrane Proteins / physiology Molecular Sequence Data Phagocytosis / physiology* Protozoan Proteins / metabolism* Protozoan Proteins / physiology Sequence Homology, Amino Acid |
| IF | 3.791 |
| 引用数 | 38 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 細胞性粘菌 | G20434 G00690 |