RRC ID 6698
Author Benghezal M, Cornillon S, Gebbie L, Alibaud L, Brückert F, Letourneur F, Cosson P.
Title Synergistic control of cellular adhesion by transmembrane 9 proteins.
Journal Mol Biol Cell
Abstract The transmembrane 9 (TM9) family of proteins contains numerous members in eukaryotes. Although their function remains essentially unknown in higher eukaryotes, the Dictyostelium discoideum Phg1a TM9 protein was recently reported to be essential for cellular adhesion and phagocytosis. Herein, the function of Phg1a and of a new divergent member of the TM9 family called Phg1b was further investigated in D. discoideum. The phenotypes of PHG1a, PHG1b, and PHG1a/PHG1b double knockout cells revealed that Phg1a and Phg1b proteins play a synergistic but not redundant role in cellular adhesion, phagocytosis, growth, and development. Complementation analysis supports a synergistic regulatory function rather than a receptor role for Phg1a and Phg1b proteins. Together, these results suggest that Phg1 proteins act as regulators of cellular adhesion, possibly by controlling the intracellular transport in the endocytic pathway and the composition of the cell surface.
Volume 14(7)
Pages 2890-9
Published 2003-7-1
DOI 10.1091/mbc.e02-11-0724
PII E02-11-0724
PMID 12857872
PMC PMC165684
MeSH Amino Acid Sequence Animals Cell Adhesion / physiology Cell Membrane / metabolism Cell Membrane / physiology Dictyostelium / growth & development Dictyostelium / metabolism* Membrane Proteins / metabolism* Membrane Proteins / physiology Molecular Sequence Data Phagocytosis / physiology* Protozoan Proteins / metabolism* Protozoan Proteins / physiology Sequence Homology, Amino Acid
IF 3.791
Times Cited 38
Cellular slime molds G20434 G00690