論文 - 詳細
| RRC ID | 68682 |
|---|---|
| 著者 | Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K. |
| タイトル | Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer. |
| ジャーナル | Cancer Sci |
| Abstract |
Aside from the human epidermal growth factor receptor-2 (HER2)-targeting agent trastuzumab, molecular targeting therapy for gastric cancer (GC) has not been established. We previously reported that apoptosis signal-regulating kinase-1 (ASK1) was upregulated in human GC and that overexpression of ASK1 promoted GC cell proliferation. Here, we investigated the effect of ASK1 inhibitor K811 on GC cells. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers. These results indicate that ASK1 inhibition prevents GC cell growth in vitro and in vivo, suggesting that ASK1 inhibitors can be potent therapeutic drugs for GC. |
| 巻・号 | 103(12) |
| ページ | 2181-5 |
| 公開日 | 2012-12-1 |
| DOI | 10.1111/cas.12024 |
| PMID | 23110662 |
| PMC | PMC7659227 |
| MeSH | Animals Antineoplastic Agents / pharmacology* Apoptosis* Cell Line, Tumor Cell Proliferation HeLa Cells Humans MAP Kinase Kinase Kinase 5 / antagonists & inhibitors* MAP Kinase Kinase Kinase 5 / genetics MAP Kinase Kinase Kinase 5 / metabolism* Mice Mice, Nude Neoplasm Transplantation Receptor, ErbB-2 / genetics Receptor, ErbB-2 / metabolism Stomach Neoplasms / drug therapy* Stomach Neoplasms / metabolism* Stomach Neoplasms / pathology Transplantation, Heterologous Up-Regulation |
| IF | 4.966 |
| リソース情報 | |
| ヒト・動物細胞 | MKN45(RCB1001) MKN74(RCB1002) MKN7(RCB0999) HuG1-N(RCB1179) |