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RRC ID 70558
Author Labana P, Dornan MH, Lafrenière M, Czarny TL, Brown ED, Pezacki JP, Boddy CN.
Title Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria.
Journal Cell Chem Biol
Volume 28(12)
Pages 1703-1715.e11
Published 2021-12-16
DOI 10.1016/j.chembiol.2021.07.001
PII S2451-9456(21)00311-1
PMID 34293284
MeSH ATPases Associated with Diverse Cellular Activities / antagonists & inhibitors* ATPases Associated with Diverse Cellular Activities / metabolism Anti-Bacterial Agents / chemical synthesis Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Bacillus subtilis / drug effects* Bacillus subtilis / enzymology Cell Division / drug effects Enzyme Inhibitors / chemical synthesis Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology* Microbial Sensitivity Tests Pyrroles / chemical synthesis Pyrroles / chemistry Pyrroles / pharmacology Spiro Compounds / chemical synthesis Spiro Compounds / chemistry Spiro Compounds / pharmacology Streptomyces / chemistry
IF 6.762
Resource
Prokaryotes B. subtilis