RRC ID 70793
Author Inoue E, Suzuki T, Shimizu Y, Sudo K, Kawasaki H, Ishida N.
Title Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.
Journal Gene
Abstract Parkinson's disease (PD) is a common neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the brain. α-Synuclein is an aggregation-prone neural protein that plays a role in the pathogenesis of PD. In our previous paper, we found that saffron; the stigma of Crocus sativus Linné (Iridaceae), and its constituents (crocin and crocetin) suppressed aggregation of α-synuclein and promoted the dissociation of α-synuclein fibrils in vitro. In this study, we investigated the effect of dietary saffron and its constituent, crocetin, in vivo on a fly PD model overexpressing several mutant α-synuclein in a tissue-specific manner. Saffron and crocetin significantly suppressed the decrease of climbing ability in the Drosophila overexpressing A30P (A30P fly PD model) or G51D (G51D fly PD model) mutated α-synuclein in neurons. Saffron and crocetin extended the life span in the G51D fly PD model. Saffron suppressed the rough-eyed phenotype and the dispersion of the size histogram of the ocular long axis in the eye of A30P fly PD model. Saffron had a cytoprotective effect on a human neuronal cell line with α-synuclein fibrils. These data showed that saffron and its constituent crocetin have protective effects on the progression of PD disease in animals in vivo and suggest that saffron and crocetin can be used to treat PD.
Volume 799
Pages 145811
Published 2021-10-5
DOI 10.1016/j.gene.2021.145811
PII S0378-1119(21)00406-6
PMID 34224829
MeSH Animals Animals, Genetically Modified Carotenoids / pharmacology* Cell Line Crocus / chemistry* Disease Models, Animal Drosophila melanogaster / genetics Female Humans Longevity / drug effects Male Motor Activity / drug effects* Mutation Neurons / drug effects Neurons / pathology Neuroprotective Agents / pharmacology Parkinson Disease / drug therapy Parkinson Disease / etiology* Retinal Degeneration / drug therapy* Retinal Degeneration / etiology Retinal Degeneration / physiopathology Vitamin A / analogs & derivatives* Vitamin A / pharmacology alpha-Synuclein / genetics alpha-Synuclein / metabolism alpha-Synuclein / toxicity
IF 2.984
Resource
Drosophila