論文 - 詳細
| RRC ID | 70851 |
|---|---|
| 著者 | Chew LY, Zhang H, He J, Yu F. |
| タイトル | The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling. |
| ジャーナル | Cell Rep |
| Abstract |
The evolutionarily conserved Nrf2-Keap1 pathway is a key antioxidant response pathway that protects cells/organisms against detrimental effects of oxidative stress. Impaired Nrf2 function is associated with cancer and neurodegenerative diseases in humans. However, the function of the Nrf2-Keap1 pathway in the developing nervous systems has not been established. Here we demonstrate a cell-autonomous role of the Nrf2-Keap1 pathway, composed of CncC/Nrf2, Keap1, and MafS, in governing neuronal remodeling during Drosophila metamorphosis. Nrf2-Keap1 signaling is activated downstream of the steroid hormone ecdysone. Mechanistically, the Nrf2-Keap1 pathway is activated via cytoplasmic-to-nuclear translocation of CncC in an importin- and ecdysone-signaling-dependent manner. Moreover, Nrf2-Keap1 signaling regulates dendrite pruning independent of its canonical antioxidant response pathway, acting instead through proteasomal degradation. This study reveals an epistatic link between the Nrf2-Keap1 pathway and steroid hormone signaling and demonstrates an antioxidant-independent but proteasome-dependent role of the Nrf2-Keap1 pathway in neuronal remodeling. |
| 巻・号 | 36(5) |
| ページ | 109466 |
| 公開日 | 2021-8-3 |
| DOI | 10.1016/j.celrep.2021.109466 |
| PII | S2211-1247(21)00889-5 |
| PMID | 34348164 |
| MeSH | Animals Antioxidants / metabolism Base Sequence Cell Nucleus / metabolism Dendrites / metabolism Drosophila Proteins / chemistry Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Ecdysone / metabolism Karyopherins / metabolism Kelch-Like ECH-Associated Protein 1 / metabolism* NF-E2-Related Factor 2 / metabolism* Neuronal Plasticity* Proteasome Endopeptidase Complex / metabolism Protein Binding Protein Domains Protein Transport Proteolysis Signal Transduction* Steroids / metabolism* |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#107554 DGRC#101586 6343R-1 6343R-2 2286R-2 |