| RRC ID |
73048
|
| 著者 |
Hong J, Ishihara K, Yamaki K, Hiraizumi K, Ohno T, Ahn JW, Zee O, Ohuchi K.
|
| タイトル |
Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
The fungal metabolite apicidin (cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)) inhibited the growth of HL-60 cells in a concentration-dependent manner (100-1000 nM). At higher concentrations (>300 nM), cell death was induced. At 100 nM, it induced hyperacetylation of histone H4 time-dependently, while trichostatin A induced transient hyperacetylation. Apicidin (10-100 nM) increased the cells having nitroblue tetrazolium-reducing activity and expressing CD11b but not CD14 and CD15. The expression of CD11b by apicidin was long lasting, while that by trichostatin A was transient. In K562 cells, apicidin at 10-100 nM did not inhibit cell growth nor express CD11b, CD14 and CD15. Our findings indicate that apicidin inhibits proliferation and induces the early stage of differentiation of HL-60 cells.
|
| 巻・号 |
189(2)
|
| ページ |
197-206
|
| 公開日 |
2003-1-28
|
| DOI |
10.1016/s0304-3835(02)00500-1
|
| PII |
S0304383502005001
|
| PMID |
12490313
|
| MeSH |
Acetylation / drug effects
Apoptosis / drug effects
CD11b Antigen / analysis
Cell Differentiation / drug effects
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology*
HL-60 Cells / cytology
HL-60 Cells / drug effects*
Histone Deacetylase Inhibitors*
Histones / metabolism
Humans
K562 Cells / drug effects
Lewis X Antigen / analysis
Lipopolysaccharide Receptors / analysis
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / metabolism
Peptides, Cyclic / pharmacology*
Protein Processing, Post-Translational / drug effects
|
| IF |
7.36
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041) |
