| RRC ID |
74689
|
| 著者 |
Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J, Zhang W.
|
| タイトル |
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
|
| ジャーナル |
Cell Mol Life Sci
|
| Abstract |
Ufmylation is a recently identified small ubiquitin-like modification, whose biological function and relevant cellular targets are poorly understood. Here we present evidence of a neuroprotective role for Ufmylation involving Autophagy-related gene 9 (Atg9) during Drosophila aging. The Ufm1 system ensures the health of aged neurons via Atg9 by coordinating autophagy and mTORC1, and maintaining mitochondrial homeostasis and JNK (c-Jun N-terminal kinase) activity. Neuron-specific expression of Atg9 suppresses the age-associated movement defect and lethality caused by loss of Ufmylation. Furthermore, Atg9 is identified as a conserved target of Ufm1 conjugation mediated by Ddrgk1, a critical regulator of Ufmylation. Mammalian Ddrgk1 was shown to be indispensable for the stability of endogenous Atg9A protein in mouse embryonic fibroblast (MEF) cells. Taken together, our findings might have important implications for neurodegenerative diseases in mammals.
|
| 巻・号 |
80(5)
|
| ページ |
129
|
| 公開日 |
2023-4-22
|
| DOI |
10.1007/s00018-023-04778-9
|
| PII |
10.1007/s00018-023-04778-9
|
| PMID |
37086384
|
| MeSH |
Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / metabolism
Aging* / genetics
Aging* / metabolism
Animals
Autophagy-Related Proteins* / genetics
Autophagy-Related Proteins* / metabolism
Brain* / metabolism
Drosophila* / metabolism
Drosophila Proteins* / genetics
Drosophila Proteins* / metabolism
Fibroblasts / metabolism
Mammals / metabolism
Membrane Proteins / metabolism
Mice
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism
|
| IF |
6.496
|
| リソース情報 |
| ショウジョウバエ |
DGRC#109029
HMS01352
HMJ30245
5862R-1 |
