Reference - Detail
| RRC ID | 75748 |
|---|---|
| Author | Jain RA, Wolman MA, Marsden KC, Nelson JC, Shoenhard H, Echeverry FA, Szi C, Bell H, Skinner J, Cobbs EN, Sawada K, Zamora AD, Pereda AE, Granato M. |
| Title | A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making. |
| Journal | Curr Biol |
| Abstract |
Animals continuously integrate sensory information and select contextually appropriate responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli from a pre-existing choice repertoire in a context-dependent manner. We demonstrate that this sensorimotor choice is modulated by stimulus quality and history, as well as by neuromodulatory systems-all hallmarks of more complex decision making. Moreover, from a genetic screen coupled with whole-genome sequencing, we identified eight mutants with deficits in this sensorimotor choice, including mutants of the vertebrate-specific G-protein-coupled extracellular calcium-sensing receptor (CaSR), whose function in the nervous system is not well understood. We demonstrate that CaSR promotes sensorimotor decision making acutely through Gαi/o and Gαq/11 signaling, modulated by clathrin-mediated endocytosis. Combined, our results identify the first set of genes critical for behavioral choice modulation in a vertebrate and reveal an unexpected critical role for CaSR in sensorimotor decision making. |
| Volume | 28(9) |
| Pages | 1357-1369.e5 |
| Published | 2018-5-7 |
| DOI | 10.1016/j.cub.2018.03.025 |
| PII | S0960-9822(18)30354-3 |
| PMID | 29681477 |
| PMC | PMC5940496 |
| MeSH | Acoustic Stimulation Animals Behavior, Animal Calcium / metabolism Choice Behavior / physiology* Genetic Testing Mutation* Psychomotor Performance* Receptors, Calcium-Sensing / genetics Receptors, Calcium-Sensing / physiology* Zebrafish / embryology Zebrafish / physiology* Zebrafish Proteins / genetics Zebrafish Proteins / physiology* |
| IF | 9.601 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 25 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | hspGFFDMC130A hspGFF62A |