| RRC ID |
76291
|
| 著者 |
Segref A, Vakkayil KL, Padvitski T, Li Q, Kroef V, Lormann J, Körner L, Finger F, Hoppe T.
|
| タイトル |
Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms.
|
| 巻・号 |
13(1)
|
| ページ |
5874
|
| 公開日 |
2022-10-5
|
| DOI |
10.1038/s41467-022-33467-7
|
| PII |
10.1038/s41467-022-33467-7
|
| PMID |
36198694
|
| PMC |
PMC9534930
|
| MeSH |
Animals
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / metabolism
Calcineurin / genetics
Calcineurin / metabolism
Forkhead Transcription Factors / genetics
Forkhead Transcription Factors / metabolism
Insulin / metabolism
Proteasome Endopeptidase Complex / metabolism
Proteolysis
Proteome / metabolism
Sensory Receptor Cells / metabolism
Transcription Factors / metabolism
Ubiquitin / metabolism
|
| リソース情報 |
| 線虫 |
tm2371
tm4791
tm445
tm1888
tm2560
tm544 |
