論文 - 詳細
| RRC ID | 76291 |
|---|---|
| 著者 | Segref A, Vakkayil KL, Padvitski T, Li Q, Kroef V, Lormann J, Körner L, Finger F, Hoppe T. |
| タイトル | Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. |
| ジャーナル | Nat Commun |
| Abstract |
Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms. |
| 巻・号 | 13(1) |
| ページ | 5874 |
| 公開日 | 2022-10-5 |
| DOI | 10.1038/s41467-022-33467-7 |
| PII | 10.1038/s41467-022-33467-7 |
| PMID | 36198694 |
| PMC | PMC9534930 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Calcineurin / genetics Calcineurin / metabolism Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Insulin / metabolism Proteasome Endopeptidase Complex / metabolism Proteolysis Proteome / metabolism Sensory Receptor Cells / metabolism Transcription Factors / metabolism Ubiquitin / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2371 tm4791 tm445 tm1888 tm2560 tm544 |