論文 - 詳細
| RRC ID | 78329 |
|---|---|
| 著者 | Sofyana NT, Refli R, Takahashi M, Sakamoto K. |
| タイトル | Oxygen nanobubble water affects wound healing of fibroblast WI-38 cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
This study investigated the usefulness of oxygen nanobubble water (O2NBW) for wound repair by analyzing its effect on the wound-healing process in human lung fibroblasts (WI-38 cells). The WI-38 cells were treated with 0%, 50%, and 100% O2NBW. The cell viability, reactive oxygen species (ROS) production, and wound healing following treatment were determined to elucidate the effects of O2NBW. Our findings revealed that O2NBW had no cytotoxic effects on WI-38 cells, but instead increased cell numbers. The production of ROS was inhibited in the presence of O2NBW. Further, O2NBW induced migration and wound closure in WI-38 cells. In addition, the mRNA expression levels of antioxidant enzymes and wound-healing-related genes were evaluated. The results demonstrated that O2NBW enhanced the expression levels of all representative genes. In conclusion, our findings suggest that O2NBW could affect ROS production and wound healing in WI-38 cells and genes associated with the antioxidant system and wound healing. |
| 巻・号 | 87(6) |
| ページ | 620-626 |
| 公開日 | 2023-5-19 |
| DOI | 10.1093/bbb/zbad026 |
| PII | 7115317 |
| PMID | 37041088 |
| MeSH | Antioxidants* / metabolism Antioxidants* / pharmacology Cell Proliferation Fibroblasts Humans Oxygen* / metabolism Oxygen* / pharmacology Reactive Oxygen Species / metabolism Wound Healing |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | WI-38(RCB0702) |