論文 - 詳細
| RRC ID | 78885 |
|---|---|
| 著者 | Taniguchi K, Nishiura H, Ota Y, Yamamoto T. |
| タイトル | Roles of the ribosomal protein S19 dimer and chemically induced apoptotic cells as a tumor vaccine in syngeneic mouse transplantation models. |
| ジャーナル | J Immunother |
| Abstract |
We examined the roles of a chemotherapeutic reagent in both inducing apoptosis and conferring acquired tumor immunity using mouse syngeneic tumor transplantation models. A chemotherapeutic reagent, cis-diamminedichloroplatinum (II), effectively induced apoptosis in Colon-26 cells originating from a BALB/c mouse. Three intradermal inoculations of cis-diamminedichloroplatinum (II)-treated Colon-26 cells conferred tumor immunity against viable Colon-26 cells in BALB/c mice but not in athymic BALB/c mice. The acquired immunity was Colon-26 cell specific and was adoptively transferable with splenic cells. We next examined the involvement of the cross-linked ribosomal protein S19 dimer (RP S19), which is released during apoptosis, in the acquisition of tumor immunity. A Colon-26 transformant that produces a Gln137Asn-mutant RP S19 prevents the formation of a functional RP S19 dimer. Acquired tumor immunity was significantly reduced when the transformant was used in combination with anti-RP S19 antibodies as the vaccination source. These data suggest the importance of the RP S19 dimer in chemotherapeutic agent-induced acquired immunity. |
| 巻・号 | 34(1) |
| ページ | 16-27 |
| 公開日 | 2011-1-1 |
| DOI | 10.1097/CJI.0b013e3181fb03ed |
| PII | 00002371-201101000-00002 |
| PMID | 21150710 |
| MeSH | Adoptive Transfer Animals Apoptosis* Blotting, Western Cancer Vaccines / immunology* Cell Line, Tumor Cisplatin / pharmacology Immunotherapy, Adoptive In Situ Nick-End Labeling Injections, Intradermal Mice Mice, Inbred BALB C Mice, Nude Mutation Neoplasm Transplantation Neoplasms, Experimental Protein Multimerization Ribosomal Proteins / immunology* Signal Transduction Transplantation, Isogeneic |
| IF | 4.11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Meth-A(RCB0464) |