| RRC ID |
81718
|
| 著者 |
Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M.
|
| タイトル |
Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA.
|
| ジャーナル |
Stem Cell Res
|
| Abstract |
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.
|
| 巻・号 |
78
|
| ページ |
103452
|
| 公開日 |
2024-8-1
|
| DOI |
10.1016/j.scr.2024.103452
|
| PII |
S1873-5061(24)00150-8
|
| PMID |
38815527
|
| MeSH |
Cell Differentiation
Cell Line
DNA, Mitochondrial* / genetics
Hearing Loss / genetics
Hearing Loss / pathology
Hearing Loss, Sensorineural / genetics
Hearing Loss, Sensorineural / pathology
Humans
Induced Pluripotent Stem Cells* / metabolism
Male
Middle Aged
Mutation*
RNA, Ribosomal / genetics
|
| IF |
4.495
|
| リソース情報 |
| ヒト・動物細胞 |
201B7(HPS0063) |
