RRC ID 81718
Author Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M.
Title Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA.
Journal Stem Cell Res
Abstract We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.
Volume 78
Pages 103452
Published 2024-8-1
DOI 10.1016/j.scr.2024.103452
PII S1873-5061(24)00150-8
PMID 38815527
MeSH Cell Differentiation Cell Line DNA, Mitochondrial* / genetics Hearing Loss / genetics Hearing Loss / pathology Hearing Loss, Sensorineural / genetics Hearing Loss, Sensorineural / pathology Humans Induced Pluripotent Stem Cells* / metabolism Male Middle Aged Mutation* RNA, Ribosomal / genetics
Resource
Human and Animal Cells 201B7(HPS0063)