論文 - 詳細
| RRC ID | 83504 |
|---|---|
| 著者 | Morozumi Y, Hayashi Y, Chu CM, Sofyantoro F, Akikusa Y, Fukuda T, Shiozaki K. |
| タイトル | Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains. |
| ジャーナル | FEBS Lett |
| Abstract |
TOR complex 1 (TORC1) is a multi-protein kinase complex that coordinates cellular growth with environmental cues. Recent studies have identified Pib2 as a critical activator of TORC1 in budding yeast. Here, we show that loss of Pib2 causes severe growth defects in fission yeast cells, particularly when basal TORC1 activity is diminished by hypomorphic mutations in tor2, the gene encoding the catalytic subunit of TORC1. Consistently, TORC1 activity is significantly compromised in the tor2 hypomorphic mutants lacking Pib2. Moreover, as in budding yeast, fission yeast Pib2 localizes to vacuolar membranes via its FYVE domain, with its tail motif indispensable for TORC1 activation. These results strongly suggest that Pib2-mediated positive regulation of TORC1 is evolutionarily conserved between the two yeast species. |
| 巻・号 | 598(23) |
| ページ | 2886-2896 |
| 公開日 | 2024-12-1 |
| DOI | 10.1002/1873-3468.14980 |
| PMID | 39010328 |
| MeSH | Conserved Sequence Evolution, Molecular Intracellular Membranes* / metabolism Mechanistic Target of Rapamycin Complex 1* / genetics Mechanistic Target of Rapamycin Complex 1* / metabolism Mutation Protein Domains Schizosaccharomyces* / genetics Schizosaccharomyces* / metabolism Schizosaccharomyces pombe Proteins* / genetics Schizosaccharomyces pombe Proteins* / metabolism Vacuoles* / metabolism |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Peer-review(Publons) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | |