論文 - 詳細
| RRC ID | 84093 |
|---|---|
| 著者 | Wong C, Jurczak EM, Roy R. |
| タイトル | Neuronal exosomes transport an miRISC cargo to preserve stem cell integrity during energy stress. |
| ジャーナル | Cell Rep |
| Abstract |
During periods of nutrient scarcity, many animals undergo germline quiescence to preserve reproductive capacity, and neurons are often necessary for this adaptation. We show here that starvation causes the release of neuronal microRNA (miRNA)/Argonaute-loaded exosomes following AMP kinase-regulated trafficking changes within serotonergic neurons. This neuron-to-germline communication is independent of classical neurotransmission but instead relies on endosome-derived vesicles that carry a pro-quiescent small RNA cargo to modify germline gene expression. Using an miRNA activity sensor, we show that neuronally expressed miRNAs can extinguish the expression of germline mRNA targets in an exosome-dependent manner. Our findings demonstrate how an adaptive neuronal response can change gene expression at a distance by redirecting intracellular trafficking to release neuronal exosomes with specific miRNA cargoes capable of tracking to their appropriate destinations. |
| 巻・号 | 43(10) |
| ページ | 114851 |
| 公開日 | 2024-10-22 |
| DOI | 10.1016/j.celrep.2024.114851 |
| PII | S2211-1247(24)01202-6 |
| PMID | 39392750 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Energy Metabolism Exosomes* / metabolism MicroRNAs* / genetics MicroRNAs* / metabolism Neurons* / metabolism Stem Cells / metabolism Stress, Physiological |
| リソース情報 | |
| 線虫 | tm1944 |