論文 - 詳細
| RRC ID | 84212 |
|---|---|
| 著者 | Gao X, Yu J, Li Y, Shi H, Zhang L, Fang M, Liu Y, Huang C, Fan S. |
| タイトル | 27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in Caenorhabditis elegans by Activating Nuclear Receptors. |
| ジャーナル | Molecules |
| Abstract |
27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show that 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), a nuclear receptor transcription factor, extending the lifespan and healthspan in Caenorhabditis elegans (C. elegans). Meanwhile, the longevity-promoting effect of 27-HMA was attenuated in the mutants of nhr-8 and daf-12, the FXR homologs, indicating that the longevity effects of 27-HMA in C. elegans may depend on nuclear hormone receptors (NHRs). Further analysis revealed potential associations between the longevity effects of 27-HMA and the insulin/insulin-like growth factor-1 signaling (IIS)/TORC1 pathway. Moreover, 27-HMA increased the toxin resistance of nematodes and activated the expression of detoxification genes, which rely on NHRs. Finally, 27-HMA improved the age-related neurodegeneration in Alzheimer's disease (AD) and Parkinson's disease (PD) C. elegans models. Taken together, our findings suggest that 27-HMA is a novel FXR agonist and may prolong lifespan and healthspan via activating NHRs. |
| 巻・号 | 30(5) |
| 公開日 | 2025-2-21 |
| DOI | 10.3390/molecules30051010 |
| PII | molecules30051010 |
| PMID | 40076235 |
| PMC | PMC11902184 |
| MeSH | Alzheimer Disease / drug therapy Alzheimer Disease / metabolism Animals Caenorhabditis elegans* / drug effects Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Disease Models, Animal Longevity* / drug effects Parkinson Disease / drug therapy Parkinson Disease / metabolism Receptors, Cytoplasmic and Nuclear* / agonists Receptors, Cytoplasmic and Nuclear* / genetics Receptors, Cytoplasmic and Nuclear* / metabolism Signal Transduction / drug effects |
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| 線虫 | tm4241 tm1800 |