RRC ID 864
Author Takechi S, Yamaguchi T, Nomura H, Minematsu T, Nakayama T.
Title Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity.
Journal Mutat Res
Abstract Dihydropyrazine (DHP) causes DNA strand breaks in vitro. We evaluated the cytotoxic and genotoxic potential of DHP in Escherichia coli. DHP exposure dose-dependently caused inhibition of cell growth in the wild-type strain, death in recA and uvrB, and an increase in mutation frequency in uvrB. These findings indicate that DHP causes DNA strand breaks in vivo.
Volume 560(1)
Pages 49-55
Published 2004-5-9
DOI 10.1016/j.mrgentox.2004.02.007
PII S1383571804000476
PMID 15099824
MeSH DNA Damage DNA, Bacterial / drug effects* Escherichia coli / drug effects* Escherichia coli / genetics Escherichia coli / growth & development Mutagenesis Pyrazines / toxicity*
IF 2.011
Times Cited 19
WOS Category TOXICOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY
Resource
Prokaryotes E. coli JE8478(GY6130) JE8479(QR140) ME8079(AB1157) ME8080(AB1885) ME8087(AB2463) ME8303(UM197) ME8299(UM119) ME8993(QC774)