論文 - 詳細
| RRC ID | 86763 |
|---|---|
| 著者 | Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF. |
| タイトル | Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. |
| ジャーナル | Nat Cell Biol |
| Abstract |
The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction. This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process. Endoglin mutant cells and blood vessels continue to enlarge in response to flow increases, thus exacerbating pre-existing embryonic arterial-venous shunts. Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs. |
| 巻・号 | 19(6) |
| ページ | 653-665 |
| 公開日 | 2017-6-1 |
| DOI | 10.1038/ncb3528 |
| PII | ncb3528 |
| PMID | 28530658 |
| PMC | PMC5455977 |
| MeSH | Animals Arteriovenous Malformations / genetics Arteriovenous Malformations / metabolism Arteriovenous Malformations / physiopathology Cell Shape* Endoglin / deficiency Endoglin / genetics Endoglin / metabolism* Endothelial Cells / metabolism* Genetic Predisposition to Disease Hemodynamics* Human Umbilical Vein Endothelial Cells / metabolism Humans Kruppel-Like Transcription Factors / genetics Kruppel-Like Transcription Factors / metabolism Mechanotransduction, Cellular* Mice, Knockout Mutation Neovascularization, Physiologic Phenotype Regional Blood Flow Stress, Mechanical Time Factors Zebrafish / embryology Zebrafish / genetics Zebrafish / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* |
| IF | 20.042 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:GFP |