論文 - 詳細
| RRC ID | 88046 |
|---|---|
| 著者 | Zhang H, Meléndez A. |
| タイトル | Conserved components of the macroautophagy machinery in Caenorhabditis elegans. |
| ジャーナル | Genetics |
| Abstract |
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and its subsequent delivery to lysosomes for degradation and recycling. In Caenorhabditis elegans, autophagy participates in diverse processes such as stress resistance, cell fate specification, tissue remodeling, aging, and adaptive immunity. Genetic screens in C. elegans have identified a set of metazoan-specific autophagy genes that form the basis for our molecular understanding of steps unique to the autophagy pathway in multicellular organisms. Suppressor screens have uncovered multiple mechanisms that modulate autophagy activity under physiological conditions. C. elegans also provides a model to investigate how autophagy activity is coordinately controlled at an organismal level. In this chapter, we will discuss the molecular machinery, regulation, and physiological functions of autophagy, and also methods utilized for monitoring autophagy during C. elegans development. |
| 巻・号 | 229(4) |
| 公開日 | 2025-4-17 |
| DOI | 10.1093/genetics/iyaf007 |
| PII | 8105738 |
| PMID | 40180610 |
| PMC | PMC12005284 |
| MeSH | Animals Autophagosomes / metabolism Autophagy* / genetics Caenorhabditis elegans* / genetics Caenorhabditis elegans* / growth & development Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Lysosomes / metabolism Macroautophagy* / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm3425 tm3948 |