Reference - Detail
| RRC ID | 88104 |
|---|---|
| Author | Santillan EM, Cormack ED, Wang J, Rodriguez-Steube M, Cochella L. |
| Title | An ancient and essential miRNA family controls cellular interaction pathways in C. elegans. |
| Journal | Sci Adv |
| Abstract |
The transition from unicellular to multicellular life required the acquisition of coordinated and regulated cellular behaviors, including adhesion and migration. In metazoans, this involves adhesion proteins, signaling systems, and an elaborate extracellular matrix (ECM) that contributes to adhesion and signaling interactions. Innovations that enabled complex multicellularity occurred through new genes in these pathways, novel functions for existing genes, and regulatory changes. Gene regulation by microRNAs (miRNAs) expanded with multicellularity. A single miRNA, miR-100, arose in the last common eumetazoan ancestor and is widely conserved across animals. We reveal the molecular function of its C. elegans homolog, the miR-51 family. This family acts in a dose-dependent manner to control morphogenesis by regulating several genes involved in cell signaling, adhesion, and migration, including ECM modifiers-specifically heparan sulfate sulfotransferases (HSTs). Some of these targets are also predicted to be conserved targets across vertebrates. Our work suggests that this miRNA provided an innovation in the regulation of cellular interactions early in metazoan evolution. |
| Volume | 11(36) |
| Pages | eadz1934 |
| Published | 2025-9-5 |
| DOI | 10.1126/sciadv.adz1934 |
| PMID | 40901950 |
| PMC | PMC12407057 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Communication* / genetics Evolution, Molecular Extracellular Matrix / genetics Extracellular Matrix / metabolism Gene Expression Regulation MicroRNAs* / genetics MicroRNAs* / metabolism Signal Transduction / genetics |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 46 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tmC9 |