論文 - 詳細
| RRC ID | 959 |
|---|---|
| 著者 | Moriuchi M, Moriuchi H, Mon HM, Kanbara H. |
| タイトル | Dichotomous effects of Plasmodium falciparum antigens on expression of human immunodeficiency virus (HIV) coreceptors and on infectability of CD4 cells by HIV. |
| ジャーナル | J Infect Dis |
| Abstract |
Many microbial coinfections accelerate the progression of human immunodeficiency virus (HIV) disease. Coinfections of Plasmodium falciparum malaria and HIV-1 are common; however, past studies of the effects of P. falciparum malaria on HIV-1 infection have shown little effect. The present study found that P. falciparum antigens (PF-Ags) variably regulate the expression of HIV-1 coreceptors and modulate the infectability of CD4 cells by HIV-1. Shortly after PF-Ag stimulation, CCR5 expression was down-regulated, but CXCR4 expression was modestly up-regulated. Subsequently, CCR5 expression on CD4 cells was induced. Infectability of PF-Ag-stimulated peripheral blood mononuclear cells (PBMC) by R5 HIV-1 was decreased, regardless of the duration of PF-Ag stimulation or CCR5 expression levels. In contrast, X4 HIV-1 replication was enhanced briefly in PBMC stimulated with PF-Ags but was inhibited with longer stimulation. Decreased HIV-1 infectability resulted, in part, from endogenous production of interferon-gamma. These results may explain why malaria previously did not appear to accelerate HIV-1 disease progression. |
| 巻・号 | 186(8) |
| ページ | 1194-7 |
| 公開日 | 2002-10-15 |
| DOI | 10.1086/343814 |
| PII | JID020520 |
| PMID | 12355376 |
| MeSH | Animals Antigens, Protozoan / metabolism* CD4-Positive T-Lymphocytes / metabolism* CD4-Positive T-Lymphocytes / virology* Down-Regulation Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation* HIV Infections / immunology HIV-1 / growth & development HIV-1 / metabolism* Humans Plasmodium falciparum / immunology Plasmodium falciparum / physiology* Receptors, CCR5 / analysis Receptors, CCR5 / genetics Receptors, CCR5 / metabolism Receptors, CXCR4 / analysis Receptors, CXCR4 / genetics Receptors, CXCR4 / metabolism Receptors, HIV / analysis Receptors, HIV / genetics Receptors, HIV / metabolism* Time Factors Up-Regulation Virus Replication |
| IF | 5.022 |
| 引用数 | 8 |
| WOS 分野 | INFECTIOUS DISEASES IMMUNOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Policy sources |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | |