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  • Search Condition : Filter (MeSH = Amyotrophic Lateral Sclerosis / genetics)
Species Resource Title
C.elegans tm324 Neurons dispose of hyperactive kinesin into glial cells for clearance.
Zebrafish Tg (hb9:Venus) , RIKEN WT Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations.
Human and Animal Cells 201B7(HPS0063) Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein.
Zebrafish Tg[UAS:mRFP1-TDP-43z] , Tg[UAS:mRFP1-CRY2olig] , Tg[UAS:opTDP-43z] , Tg[mnr2b-hs:EGFP-TDP-43z] , Tg[mnr2b-hs:opTDP-43h] , Tg[mnr2b-hs:opTDP-43hA315T] Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons.
Drosophila RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration.
Drosophila Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
Drosophila Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Drosophila Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.
Drosophila RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
DNA material GFP-OPTN-WT (RDB16707) , GFP-OPTN-E50K (RDB16708) , GFP-OPTN-E478G (RDB16709) Determination of cytoplasmic optineurin foci sizes using image correlation spectroscopy.
Human and Animal Cells 201B7(HPS0063) , HPS0251 , HPS0252 , HPS0292 A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
C.elegans tm1 , tm4439 FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
DNA material CMV:TDP43-GFP (RDB15742) , CMV:GFP-TDP25 (RDB15743) , CMV:GFP-NLS-TDP25 (RDB15744) , CMV:GFP-NLSNP-TDP25 (RDB15745) , GFP-NLS NP (RDB15746) , mCherry-Ubiquitin (RDB15747). Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity.
DNA material pEF-BOS FLAG-mouse Rab29 (RDB14971) , pEF-BOS FLAG-mouse Rab29-Q67L (RDB14972) , pEF-BOS FLAG-mouse Rab29-T21N (RDB14973). C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.
DNA material Genome Network Project Human cDNA IRAL001I24 (HGY080616) FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
C.elegans tm4439 Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
C.elegans tm1411 VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
C.elegans tm4391 , tm4720 , tm4076 , tm4396 The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
C.elegans tm1447 , tm1877 Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
Human and Animal Cells NB2a(RCB2639) DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity.