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  • Search Condition : Filter (MeSH = Cyclin-Dependent Kinase 4 / genetics)
Species Resource Title
Human and Animal Cells LACF-NaNaII(RCB2320) Expression of human cell cycle regulators in the primary cell line of the African savannah elephant (loxodonta africana) increases proliferation until senescence, but does not induce immortalization.
DNA material , Human and Animal Cells pENTR4-H1tetOx1 (RDB07916) , THP-1(RCB1189) Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (REB04393) Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta).
Human and Animal Cells Ca9-22(RCB1976) , HSC-2(RCB1945) , HSC-3(RCB1975) , HSC-4(RCB1902) , Sa3(RCB0980) , SAS(RCB1974) TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.
Drosophila 4006R-3 Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.
DNA material CSII-CMV-RfA (RDB04386) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.
DNA material AxCANCre (RDB01748) The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
Human and Animal Cells K562 Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation.
DNA material CSII-CMV-RfA (RDB04386) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase.
DNA material CSII-CMV-RfA (RDB04386) , CSII-EF-RfA (RDB04387). A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.
DNA material CSII-EF-MCS (RDB04378) Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells.
Human and Animal Cells GE1(RCB1709) Establishment of human dental epithelial cell lines expressing ameloblastin and enamelin by transfection of hTERT and cdk4 cDNAs.
DNA material Ax1w1 (RDB01746) Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6.