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  • Search Condition : Filter (MeSH = Guanine Nucleotide Exchange Factors / chemistry)
Species Resource Title
DNA material pMRX-puro-EGFP-FLCN (RDB17951) , pMRX-puro-EGFP-DENND1A (RDB17952) , pMRX-puro-EGFP-DENND1B (RDB17953) , pMRX-puro-EGFP-DENND1C (RDB17954) Rab35-GEFs, DENND1A and folliculin differentially regulate podocalyxin trafficking in two- and three-dimensional epithelial cell cultures.
DNA material pEF-T7-HPS4(S541A/N543A) (RDB17367) , pEF-T7-HPS4(G55W/G59M) (RDB17368) , pEF-FLAG-HPS1 (RDB17369) , pGBD-C1-Rab6D-deltaCys-T45N (RDB17399) , pGBD-C1-Rab40AL-deltaCys-S28N (RDB17444) , pGBD-C1-Rab6D-deltaCys-Q89L (RDB18834) , pGBD-C1-Rab40AL-deltaCys-Q73L (RDB18924) The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis.
Human and Animal Cells COS-7(RCB0539) Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.
Cellular slime molds G90307 The F-actin-binding RapGEF GflB is required for efficient macropinocytosis in Dictyostelium.
DNA material pGBD-C1-Rab32-delta Cys-T37N (RDB17428) , pGBD-C1-Rab33A-delta Cys-T50N (RDB17429) , pGBD-C1-Rab33B-delta Cys-T47N (RDB17430) , pGBD-C1-Rab34-delta Cys-T66N (RDB17431) , pGBD-C1-Rab35-delta Cys-S22N (RDB17432) , pGBD-C1-Rab36-delta Cys-T71N (RDB17433) , pGBD-C1-Rab37-delta Cys-T43N (RDB17434) , pGBD-C1-Rab38-delta Cys-T23N (RDB17435) , pGBD-C1-Rab39A-delta Cys-S22N (RDB17436) , pGBD-C1-Rab39B-delta Cys-S22N (RDB17437) , ... Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
C.elegans tm1512 , tm1555 Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.
C.elegans tm1956 , tm1877 , tm3124 , tm1447 Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.
Prokaryotes E. coli pJB861 The Chromobacterium violaceum type III effector CopE, a guanine nucleotide exchange factor for Rac1 and Cdc42, is involved in bacterial invasion of epithelial cells and pathogenesis.
Yeast FY12587 Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.
Yeast cDNA libraries Role of guanine nucleotide exchange factors for Rho family GTPases in the regulation of cell morphology and actin cytoskeleton in fission yeast.
Human and Animal Cells 293T(RCB2202) The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
C.elegans tm1909 CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.
Drosophila Specific retention of the protostome-specific PsGEF may parallel with the evolution of mushroom bodies in insect and lophotrochozoan brains.