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  • Search Condition : Filter (MeSH = rab27 GTP-Binding Proteins)
Species Resource
DNA material pGEX-4T-3-Slac2-b-SHD (RDB17372) Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.
DNA material Slp4-a (RDB03421) , pEF-T7-mouse Slac2-b (RDB15095) , pEF-FLAG-mouse Munc18-1 (RDB15177). Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.
DNA material pEF-FLAG-mouse Rab12 (RDB15393) , pEF-FLAG-mouse Rab36 (RDB15395). Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
DNA material pEGFP-C1-human DENN (RDB15288) , pEGFP-C1-mouse DENND1A (RDB15289) , pEGFP-C1-mouse DENND3 (RDB15290). MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
DNA material pEGFP-C1-human TBC1D1 (RDB14982) , pEGFP-C1-human TBC1D2A (RDB14983) , pEGFP-C1-human TBC1D3 (RDB14985) , pEGFP-C1-human TBC1D4 (RDB14986) , pEGFP-C1-human TBC1D5 (RDB14987) , pEGFP-C1-human TBC1D6 (RDB14988) , pEGFP-C1-human TBC1D8A (RDB14990) , pEGFP-C1-human TBC1D8B (RDB14991) , pEGFP-C1-human TBC1D9A (RDB14992) , pEGFP-C1-human TBC1D9B (RDB14993) , ... Identification of EPI64 as a GTPase-activating protein specific for Rab27A.
DNA material pmRFP-C1-mouse rabphilin (RDB15094) The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells.
DNA material pEF-T7-mouse Slac2-c (RDB15096) , pEF-FLAG-mouse myosin Va BR-tail (Brain type) (RDB15284) , pEF-FLAG-mouse myosin Va MC-tail (Melanocyte type) (RDB15285) , pEF-FLAG-mouse myosin VIIa-tail (RDB15287). Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin.
DNA material pEF-T7-mouse Noc2 (RDB15097) Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
DNA material pCMV-Mreg delta C/MST-mStr(RDB15184) , pCMV-Mreg delta C/MST-mStr-Rab27A-QL/CA (RDB15185) , pmStr-N1-Mreg (RDB15183). The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: development of a novel melanosome-targetinG tag.
DNA material pEF-mouse T7-Munc13-4 (RDB15181) Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.
DNA material Slp4-a (RDB034219 , Rab27A (RDB03423). Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.
DNA material Slac2-a (RDB03422) , Rab27A (RDB03423) , pEF-FLAG-mouse Rab8A (RDB14271) , pEF-FLAG-mouse Rab10 (RDB14272) , pEF-BOS FLAG-mouse Rab2A (RDB14675) , pEF-BOS FLAG-mouse Rab5A (RDB14677) , pEF-BOS FLAG-mouse Rab7 (RDB14678). The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
DNA material Slac2-a (RDB03422) , pEF-FLAG-mouse myosin Va (Brain type) (RDB15283) , pEF-FLAG-mouse Rab34 (RDB15394). Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.
Human and Animal Cells Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.