論文 - 詳細
| RRC ID | 11149 |
|---|---|
| 著者 | del Alamo D, Mlodzik M. |
| タイトル | Frizzled/PCP-dependent asymmetric neuralized expression determines R3/R4 fates in the Drosophila eye. |
| ジャーナル | Dev Cell |
| Abstract |
Planar cell polarity (PCP) is a common feature in many epithelia, reflected in cellular organization within the plane of an epithelium. In the Drosophila eye, Frizzled (Fz)/PCP signaling induces cell-fate specification of the R3/R4 photoreceptors through regulation of Notch activation in R4. Except for Dl upregulation in R3, the mechanism of how Fz/PCP signaling regulates Notch in this context is not understood. We demonstrate that the E3-ubiquitin ligase Neuralized (Neur), required for Dl-N signaling, is asymmetrically expressed within the R3/R4 pair. It is required in R3, where it is also upregulated in a Fz/PCP-dependent manner. As is the case for Dl, N activity in R4 further represses neur expression, thus, reinforcing the asymmetry. We demonstrate that Neur asymmetry is instructive in correct R3/R4 specification. Our data indicate that Fz/PCP-dependent Neur expression in R3 ensures the proper directionality of Dl-N signaling during R3/R4 specification. |
| 巻・号 | 11(6) |
| ページ | 887-94 |
| 公開日 | 2006-12-1 |
| DOI | 10.1016/j.devcel.2006.09.016 |
| PII | S1534-5807(06)00409-6 |
| PMID | 17141162 |
| MeSH | Animals Animals, Genetically Modified Cell Lineage Cell Polarity* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Eye / embryology* Eye / metabolism Fluorescent Antibody Technique Frizzled Receptors / genetics Frizzled Receptors / metabolism* Gene Expression Regulation, Developmental Intracellular Signaling Peptides and Proteins Membrane Proteins / genetics Membrane Proteins / metabolism Photoreceptor Cells, Invertebrate Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / metabolism* Receptors, Notch / genetics Receptors, Notch / metabolism Receptors, Phencyclidine / genetics Receptors, Phencyclidine / metabolism* Signal Transduction Ubiquitin-Protein Ligases / genetics Ubiquitin-Protein Ligases / metabolism* |
| IF | 10.092 |
| 引用数 | 25 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | NP line |