論文 - 詳細
| RRC ID | 11683 |
|---|---|
| 著者 | Sato D, Sugimura K, Satoh D, Uemura T. |
| タイトル | Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity. |
| ジャーナル | Genes Cells |
| Abstract |
Diverse neuronal subtypes develop distinctive morphologies of dendritic arbors that receive synaptic or sensory inputs. Dendritic arbors of many subtypes take on a polarized shape, and one underlying mechanism is unidirectionally biased elongation of dendritic branches. As reported herein, we found that Drosophila Crossveinless-c (Cv-c) was a key regulator for such directional growth. In the cv-c mutant, two subclass of multidendritic sensory neurons examined formed dorsally directed branches; however, dendritic branches had difficulty in growing along the anterior-posterior (A-P) body axis. Cv-c belongs to the family of Rho GTPase-activating proteins (RhoGAPs) and is the homolog of human tumor suppressor DLC1. The RhoGAP activity of Cv-c was required cell-autonomously for the A-P-oriented growth, and Cv-c elevated the GTPase activity of Rho1 and Cdc42 in a cell-free assay. Our analysis of genetic interactions suggested that Rho1 was the target of Cv-c in vivo. All of our results suggest that Cv-c contributes to sprouting and subsequent growth of the A-P-oriented branches through negative regulation of Rho1. We discuss a role of Cv-c in dendritic growth in response to environmental cues. |
| 巻・号 | 15(5) |
| ページ | 485-500 |
| 公開日 | 2010-5-1 |
| DOI | 10.1111/j.1365-2443.2010.01399.x |
| PII | GTC1399 |
| PMID | 20384791 |
| MeSH | Alternative Splicing Animals Body Patterning / physiology Dendrites / metabolism* Dendrites / ultrastructure* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster* / anatomy & histology Drosophila melanogaster* / physiology GTPase-Activating Proteins / genetics GTPase-Activating Proteins / metabolism* Humans Phenotype Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Tumor Suppressor Proteins / genetics Tumor Suppressor Proteins / metabolism rac GTP-Binding Proteins / genetics rac GTP-Binding Proteins / metabolism rho GTP-Binding Proteins / genetics rho GTP-Binding Proteins / metabolism* |
| IF | 1.655 |
| 引用数 | 7 |
| WOS 分野 | GENETICS & HEREDITY CELL BIOLOGY |
| オルトメトリクス指標 |
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| 各媒体での言及数の合計 | 0 |
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