| RRC ID |
11683
|
| 著者 |
Sato D, Sugimura K, Satoh D, Uemura T.
|
| タイトル |
Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity.
|
| ジャーナル |
Genes Cells
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| Abstract |
Diverse neuronal subtypes develop distinctive morphologies of dendritic arbors that receive synaptic or sensory inputs. Dendritic arbors of many subtypes take on a polarized shape, and one underlying mechanism is unidirectionally biased elongation of dendritic branches. As reported herein, we found that Drosophila Crossveinless-c (Cv-c) was a key regulator for such directional growth. In the cv-c mutant, two subclass of multidendritic sensory neurons examined formed dorsally directed branches; however, dendritic branches had difficulty in growing along the anterior-posterior (A-P) body axis. Cv-c belongs to the family of Rho GTPase-activating proteins (RhoGAPs) and is the homolog of human tumor suppressor DLC1. The RhoGAP activity of Cv-c was required cell-autonomously for the A-P-oriented growth, and Cv-c elevated the GTPase activity of Rho1 and Cdc42 in a cell-free assay. Our analysis of genetic interactions suggested that Rho1 was the target of Cv-c in vivo. All of our results suggest that Cv-c contributes to sprouting and subsequent growth of the A-P-oriented branches through negative regulation of Rho1. We discuss a role of Cv-c in dendritic growth in response to environmental cues.
|
| 巻・号 |
15(5)
|
| ページ |
485-500
|
| 公開日 |
2010-5-1
|
| DOI |
10.1111/j.1365-2443.2010.01399.x
|
| PII |
GTC1399
|
| PMID |
20384791
|
| MeSH |
Alternative Splicing
Animals
Body Patterning / physiology
Dendrites / metabolism*
Dendrites / ultrastructure*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster* / anatomy & histology
Drosophila melanogaster* / physiology
GTPase-Activating Proteins / genetics
GTPase-Activating Proteins / metabolism*
Humans
Phenotype
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / metabolism
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism
rac GTP-Binding Proteins / genetics
rac GTP-Binding Proteins / metabolism
rho GTP-Binding Proteins / genetics
rho GTP-Binding Proteins / metabolism*
|
| IF |
1.655
|
| 引用数 |
7
|
|
WOS 分野
|
GENETICS & HEREDITY
CELL BIOLOGY
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| リソース情報 |
| ショウジョウバエ |
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