RRC ID 12324
Author Shirai T, Yorimitsu T, Kiritooshi N, Matsuzaki F, Nakagoshi H.
Title Notch signaling relieves the joint-suppressive activity of Defective proventriculus in the Drosophila leg.
Journal Dev. Biol.
Abstract Segmentation plays crucial roles during morphogenesis. Drosophila legs are divided into segments along the proximal-distal axis by flexible structures called joints. Notch signaling is necessary and sufficient to promote leg growth and joint formation, and is activated in distal cells of each segment in everting prepupal leg discs. The homeobox gene defective proventriculus (dve) is expressed in regions both proximal and distal to the intersegmental folds at 4 h after puparium formation (APF). Dve-expressing region partly overlaps with the Notch-activated region, and they become a complementary pattern at 6 h APF. Interestingly, dve mutant legs resulted in extra joint formation at the center of each tarsal segment, and the forced expression of dve caused a jointless phenotype. We present evidence that Dve suppresses the potential joint-forming activity, and that Notch signaling represses Dve expression to form joints.
Volume 312(1)
Pages 147-56
Published 2007-12-1
DOI 10.1016/j.ydbio.2007.09.003
PII S0012-1606(07)01339-5
PMID 17950268
MeSH Animals Cell Polarity Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Extremities / embryology* Gene Expression Regulation, Developmental Homeodomain Proteins / metabolism* Joints / cytology Joints / embryology Joints / metabolism* Models, Biological Mutation / genetics Phenotype Receptor, Epidermal Growth Factor / metabolism Receptors, Notch / metabolism* Signal Transduction* Time Factors
IF 3.262
Times Cited 18
WOS Category DEVELOPMENTAL BIOLOGY
Resource
Drosophila NP4281 (DGRC#113424)