RRC ID 12684
Author Kagami A, Sakuno T, Yamagishi Y, Ishiguro T, Tsukahara T, Shirahige K, Tanaka K, Watanabe Y.
Title Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.
Journal EMBO Rep.
Abstract In fission yeast, meiotic mono-orientation of sister kinetochores is established by cohesion at the core centromere, which is established by a meiotic cohesin complex and the kinetochore protein Moa1. The cohesin subunit Psm3 is acetylated by Eso1 and deacetylated by Clr6. We show that in meiosis, Eso1 is required for establishing core centromere cohesion during S phase, whereas Moa1 is required for maintaining this cohesion after S phase. The clr6-1 mutation suppresses the mono-orientation defect of moa1Δ cells, although the Clr6 target for this suppression is not Psm3. Thus, several acetylations are crucial for establishing and maintaining core centromere cohesion.
Volume 12(11)
Pages 1189-95
Published 2011-10-28
DOI 10.1038/embor.2011.188
PII embor2011188
PMID 21979813
PMC PMC3207105
MeSH Acetylation DNA Replication Meiosis* Meiotic Prophase I Models, Biological Mutation / genetics Protein Subunits / metabolism Schizosaccharomyces / cytology* Schizosaccharomyces / metabolism* Schizosaccharomyces pombe Proteins / metabolism
IF 8.749
Times Cited 13
Yeast strains?