論文 - 詳細
| RRC ID | 1584 |
|---|---|
| 著者 | Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I. |
| タイトル | Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. |
| ジャーナル | J Cell Biol |
| Abstract |
The concept of the plasticity or transdifferentiation of adult stem cells has been challenged by the phenomenon of cell fusion. In this work, we examined whether neonatal cardiomyocytes fuse with various somatic cells including endothelial cells, cardiac fibroblasts, bone marrow cells, and endothelial progenitor cells spontaneously in vitro. When cardiomyocytes were cocultured with endothelial cells or cardiac fibroblasts, they fused and showed phenotypes of cardiomyocytes. Furthermore, cardiomyocytes reentered the G2-M phase in the cell cycle after fusing with proliferative noncardiomyocytes. Transplanted endothelial cells or skeletal muscle-derived cells fused with adult cardiomyocytes in vivo. In the cryoinjured heart, there were Ki67-positive cells that expressed both cardiac and endothelial lineage marker proteins. These results suggest that cardiomyocytes fuse with other cells and enter the cell cycle by maintaining their phenotypes. |
| 巻・号 | 167(2) |
| ページ | 351-63 |
| 公開日 | 2004-10-25 |
| DOI | 10.1083/jcb.200312111 |
| PII | jcb.200312111 |
| PMID | 15492039 |
| PMC | PMC2172538 |
| MeSH | Adenoviridae / genetics Animals Animals, Genetically Modified Cell Communication Cell Cycle Cell Differentiation Cell Division Cell Lineage Cell Proliferation Cell Transplantation Cells, Cultured Endothelium, Vascular / cytology Endothelium, Vascular / metabolism Fibroblasts / metabolism G2 Phase Green Fluorescent Proteins / metabolism Immunohistochemistry Ki-67 Antigen / biosynthesis Lac Operon Male Mice Models, Genetic Muscle, Skeletal / cytology Myocytes, Cardiac / metabolism* Nocodazole / pharmacology Phenotype Rats Rats, Wistar Recombination, Genetic Time Factors Transgenes |
| IF | 8.811 |
| 引用数 | 93 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | AxCANCre (RDB01748) |