論文 - 詳細
| RRC ID | 18728 |
|---|---|
| 著者 | Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation. |
| ジャーナル | Cell Immunol |
| Abstract |
The involvement of retinoblastoma protein-interacting zinc finger 1 (RIZ1), a tumor suppressor, in lipopolysaccharide (LPS)-induced inflammatory responses was investigated by using RAW 264.7 macrophage-like cells. LPS significantly augmented the expression of RIZ1 and the augmentation was mediated by the activation of nuclear factor (NF)-kappaB and Akt. The silencing of RIZ1 with the siRNA led to the inactivation of NF-kappaB in response to LPS. Moreover, the RIZ1 silencing caused the down-regulation of p53 activation and a p53 pharmacological inhibitor attenuated the RIZ1 expression. LPS-induced tumor necrosis factor-alpha and interleukin-6 production was prevented by RIZ1 siRNA or a p53 pharmacological inhibitor. Therefore, RIZ1 was suggested to augment LPS-induced NF-kappaB activation in collaboration with p53 and enhance the production of proinflammatory cytokines in response to LPS. |
| 巻・号 | 264(2) |
| ページ | 114-8 |
| 公開日 | 2010-1-1 |
| DOI | 10.1016/j.cellimm.2010.05.007 |
| PII | S0008-8749(10)00128-0 |
| PMID | 20557878 |
| MeSH | Animals Cell Line Cloning, Molecular Histone-Lysine N-Methyltransferase / genetics Histone-Lysine N-Methyltransferase / immunology Histone-Lysine N-Methyltransferase / metabolism* Inflammation Interleukin-6 / biosynthesis* Interleukin-6 / genetics Interleukin-6 / metabolism Lipopolysaccharides / immunology Lipopolysaccharides / metabolism Macrophages / immunology Macrophages / metabolism* Macrophages / pathology Mice Mutation / genetics NF-kappa B / genetics NF-kappa B / metabolism* RNA, Small Interfering / genetics Transcription Factors / genetics Transcription Factors / immunology Transcription Factors / metabolism* Transcriptional Activation / genetics Tumor Necrosis Factor-alpha / biosynthesis* Tumor Necrosis Factor-alpha / genetics Tumor Necrosis Factor-alpha / metabolism Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / metabolism |
| IF | 4.078 |
| 引用数 | 3 |
| WOS 分野 | IMMUNOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |