論文 - 詳細
| RRC ID | 18746 |
|---|---|
| 著者 | Shadat NM, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53. |
| ジャーナル | Cancer Invest |
| Abstract |
The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) on the cell growth of mouse and human monocytic leukemia cells was examined. RIZ1 expression was induced in response to tumor necrosis factor (TNF)-α. The expression was dependent on the nuclear factor-κB and AKT signaling. Further, RIZ1 expression led to the augmentation of p53 expression and the silencing of RIZ1 prevented it. On the other hand, a p53 inhibitor enhanced the TNF-α-induced RIZ1 expression. Silencing of RIZ1 augmented the proliferative activity of TNF-α-treated cells. Therefore, it is suggested that RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53. |
| 巻・号 | 28(8) |
| ページ | 806-12 |
| 公開日 | 2010-10-1 |
| DOI | 10.3109/07357907.2010.494323 |
| PMID | 20594067 |
| MeSH | Animals Cell Division / drug effects DNA Methylation DNA Primers DNA-Binding Proteins / genetics DNA-Binding Proteins / pharmacology* Gene Expression Regulation, Neoplastic Gene Silencing Histone-Lysine N-Methyltransferase / genetics Histone-Lysine N-Methyltransferase / pharmacology* Homeostasis Humans Leukemia, Myeloid / genetics Leukemia, Myeloid / pathology* Mice Neoplasms / genetics Neoplasms / pathology Nuclear Proteins / genetics Nuclear Proteins / pharmacology* Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / genetics Transcription Factors / pharmacology* Transfection Tumor Necrosis Factor-alpha / genetics Tumor Suppressor Protein p53 / drug effects Tumor Suppressor Protein p53 / metabolism* |
| IF | 2.398 |
| 引用数 | 11 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |