論文 - 詳細
| RRC ID | 22000 |
|---|---|
| 著者 | Warrington SJ, Strutt H, Strutt D. |
| タイトル | The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. |
| ジャーナル | Development |
| Abstract |
Polarised tissue elongation during morphogenesis involves cells within epithelial sheets or tubes making and breaking intercellular contacts in an oriented manner. Growing evidence suggests that cell adhesion can be modulated by endocytic trafficking of E-cadherin (E-cad), but how this process can be polarised within individual cells is poorly understood. The Frizzled (Fz)-dependent core planar polarity pathway is a major regulator of polarised cell rearrangements in processes such as gastrulation, and has also been implicated in regulation of cell adhesion through trafficking of E-cad; however, it is not known how these functions are integrated. We report a novel role for the core planar polarity pathway in promoting cell intercalation during tracheal tube morphogenesis in Drosophila embryogenesis, and present evidence that this is due to regulation of turnover and levels of junctional E-cad by the guanine exchange factor RhoGEF2. Furthermore, we show that core pathway activity leads to planar-polarised recruitment of RhoGEF2 and E-cad turnover in the epidermis of both the embryonic germband and the pupal wing. We thus reveal a general mechanism by which the core planar polarity pathway can promote polarised cell rearrangements. |
| 巻・号 | 140(5) |
| ページ | 1045-54 |
| 公開日 | 2013-3-1 |
| DOI | 10.1242/dev.088724 |
| PII | dev.088724 |
| PMID | 23364328 |
| PMC | PMC3583042 |
| MeSH | Animals Animals, Genetically Modified Body Patterning / genetics* Body Patterning / physiology Cadherins / genetics Cadherins / metabolism* Cell Cycle Proteins Cell Polarity / genetics* Cell Polarity / physiology Cells, Cultured Drosophila / embryology Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila Proteins / physiology* Embryo, Nonmammalian Frizzled Receptors / genetics Frizzled Receptors / metabolism Frizzled Receptors / physiology* Protein Binding Protein Transport / physiology Proteolysis Signal Transduction / genetics Signal Transduction / physiology Trachea / embryology Trachea / metabolism rho GTP-Binding Proteins / metabolism* rho GTP-Binding Proteins / physiology |
| IF | 5.611 |
| 引用数 | 52 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |