RRC ID 22013
著者 Takeishi A, Kuranaga E, Tonoki A, Misaki K, Yonemura S, Kanuka H, Miura M.
タイトル Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila.
ジャーナル Cell Rep
Abstract Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which the response of each tissue is tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that in the systemic response to wounding, an apoptotic caspase pathway is activated downstream of reactive oxygen species in the midgut enterocytes (ECs), cells distant from the wound site, in Drosophila. We show that a caspase-pathway mutant has defects in homeostatic gut cell renewal and that inhibiting caspase activity in fly ECs results in the production of systemic lethal factors after wounding. Our results indicate that wounding remotely controls caspase activity in ECs, which activates the tissue stem cell regeneration pathway in the gut to dampen the dangerous systemic wound reaction.
巻・号 3(3)
ページ 919-30
公開日 2013-3-28
DOI 10.1016/j.celrep.2013.02.022
PII S2211-1247(13)00098-3
PMID 23523355
MeSH Animals Apoptosis* Caspases / genetics Caspases / metabolism Cell Proliferation* Drosophila / metabolism* Drosophila / physiology Enterocytes / metabolism* Enterocytes / physiology Homeostasis Intestines / injuries Mutation Reactive Oxygen Species / metabolism Wound Healing*
IF 8.109
引用数 31
WOS 分野 CELL BIOLOGY
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