論文 - 詳細
| RRC ID | 22013 |
|---|---|
| 著者 | Takeishi A, Kuranaga E, Tonoki A, Misaki K, Yonemura S, Kanuka H, Miura M. |
| タイトル | Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila. |
| ジャーナル | Cell Rep |
| Abstract |
Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which the response of each tissue is tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that in the systemic response to wounding, an apoptotic caspase pathway is activated downstream of reactive oxygen species in the midgut enterocytes (ECs), cells distant from the wound site, in Drosophila. We show that a caspase-pathway mutant has defects in homeostatic gut cell renewal and that inhibiting caspase activity in fly ECs results in the production of systemic lethal factors after wounding. Our results indicate that wounding remotely controls caspase activity in ECs, which activates the tissue stem cell regeneration pathway in the gut to dampen the dangerous systemic wound reaction. |
| 巻・号 | 3(3) |
| ページ | 919-30 |
| 公開日 | 2013-3-28 |
| DOI | 10.1016/j.celrep.2013.02.022 |
| PII | S2211-1247(13)00098-3 |
| PMID | 23523355 |
| MeSH | Animals Apoptosis* Caspases / genetics Caspases / metabolism Cell Proliferation* Drosophila / metabolism* Drosophila / physiology Enterocytes / metabolism* Enterocytes / physiology Homeostasis Intestines / injuries Mutation Reactive Oxygen Species / metabolism Wound Healing* |
| IF | 8.109 |
| 引用数 | 31 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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