論文 - 詳細
| RRC ID | 22021 |
|---|---|
| 著者 | Sakurai A, Koganezawa M, Yasunaga K, Emoto K, Yamamoto D. |
| タイトル | Select interneuron clusters determine female sexual receptivity in Drosophila. |
| ジャーナル | Nat Commun |
| Abstract |
Female Drosophila with the spinster mutation repel courting males and rarely mate. Here we show that the non-copulating phenotype can be recapitulated by the elimination of spinster functions from either spin-A or spin-D neuronal clusters, in the otherwise wild-type (spinster heterozygous) female brain. Spin-D corresponds to the olfactory projection neurons with dendrites in the antennal lobe VA1v glomerulus that is fruitless-positive, sexually dimorphic and responsive to fly odour. Spin-A is a novel local neuron cluster in the suboesophageal ganglion, which is known to process contact chemical pheromone information and copulation-related signals. A slight reduction in spinster expression to a level with a minimal effect is sufficient to shut off female sexual receptivity if the dominant-negative mechanistic target of rapamycin is simultaneously expressed, although the latter manipulation alone has only a marginal effect. We propose that spin-mediated mechanistic target of rapamycin signal transduction in these neurons is essential for females to accept the courting male. |
| 巻・号 | 4 |
| ページ | 1825 |
| 公開日 | 2013-5-7 |
| DOI | 10.1038/ncomms2837 |
| PII | ncomms2837 |
| PMID | 23652013 |
| PMC | PMC3674241 |
| MeSH | Animals Copulation / drug effects Drosophila Proteins / metabolism Drosophila melanogaster / cytology* Drosophila melanogaster / drug effects Drosophila melanogaster / physiology* Female Heterozygote Homozygote Interneurons / cytology* Interneurons / drug effects Interneurons / metabolism Male Membrane Proteins / metabolism Neuroglia / cytology Neuroglia / drug effects Neuroglia / metabolism Neurons / cytology Neurons / drug effects Neurons / metabolism Olfactory Pathways / drug effects Olfactory Pathways / metabolism RNA Interference / drug effects Receptors, Odorant / metabolism Sexual Behavior, Animal / drug effects Sexual Behavior, Animal / physiology* Signal Transduction / drug effects Sirolimus / pharmacology TOR Serine-Threonine Kinases / antagonists & inhibitors TOR Serine-Threonine Kinases / metabolism |
| IF | 12.121 |
| 引用数 | 24 |
| WOS 分野 | CELL BIOLOGY |
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| ショウジョウバエ | |