RRC ID 22043
著者 Cheng X, Jiang H, Li W, Lv H, Gong Z, Liu L.
タイトル Ten-a affects the fusion of central complex primordia in Drosophila.
ジャーナル PLoS One
Abstract The central complex of Drosophila melanogaster plays important functions in various behaviors, such as visual and olfactory memory, visual orientation, sleep, and movement control. However little is known about the genes regulating the development of the central complex. Here we report that a mutant gene affecting central complex morphology, cbd (central brain defect), was mapped to ten-a, a type II trans-membrane protein coding gene. Down-regulation of ten-a in pan-neural cells contributed to abnormal morphology of central complex. Over-expression of ten-a by C767-Gal4 was able to partially restore the abnormal central complex morphology in the cbd mutant. Tracking the development of FB primordia revealed that C767-Gal4 labeled interhemispheric junction that separated fan-shaped body precursors at larval stage withdrew to allow the fusion of the precursors. While the C767-Gal4 labeled structure did not withdraw properly and detached from FB primordia, the two fan-shaped body precursors failed to fuse in the cbd mutant. We propose that the withdrawal of C767-Gal4 labeled structure is related to the formation of the fan-shaped body. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation.
巻・号 8(2)
ページ e57129
公開日 2013-2-20
DOI 10.1371/journal.pone.0057129
PII PONE-D-12-25009
解説 PMC3577759
PMID 23437330
PMC PMC3577759
MeSH Animals Animals, Genetically Modified Axons / metabolism Brain / embryology Brain / metabolism Chromosome Mapping Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Gene Order Morphogenesis / genetics Mutation Phenotype RNA Interference Receptors, Cell Surface / genetics* Receptors, Cell Surface / metabolism
IF 2.74
引用数 5
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ NP6510 (DGRC#113956)